L’école universitaire de recherche Implanteus, propose pour sa sixième année un cycle de conférences en ligne & en présentiel.
La cinquième conférence de l’année universitaire aura lieu :
Mercredi 15 avril de 2H30 à 4H30 pm en vidéo
https://bbb.univ-avignon.fr/rooms/fay-vdw-wco
« New therapeutic approaches for the modulation of metabolic homeostasis and thermogenesis in adipose tissue«
Irene Concepción POMARES BRI
PhD Student, Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche(Spain)
Abstract:
This research investigates the potential of polyphenols as therapeutic agents to ameliorate obesity by modulating adipose tissue plasticity. Two main strategies were addressed: the induction of thermogenic activation through UCP1 upregulation, and the improvement of insulin resistance. Both approaches were evaluated using a human hyperglycemic adipocyte model (SGBS).
In this context, specific polyphenols were identified as effective inducers of UCP1-mediated thermogenesis. Moreover, metabolomic and lipidomic analyses demonstrated that verbascoside and ferulic acid can reverse metabolic dysfunction associated with glucotoxicity. Additionally, a pilot study in individuals with obesity showed that a dietary supplement enhanced brown adipose tissue activation.
Overall, these findings support the potential of selected polyphenols as nutraceutical agents to promote adipose tissue browning and restore metabolic homeostasis.
Short Bio:
I am a PhD researcher specialized in Healthcare Biotechnology, with a strong focus on metabolic disease and bioactive compounds. I completed the PhD with Cum Laude and a European Mention at Miguel Hernández University the last February, supported by a prestigious FPU fellowship from the Spanish Ministry of Universities. My research is focused on the identification of polyphenols, capable of modulating adipose tissue plasticity as a therapeutic strategy against obesity. Specifically, my work explores the induction of white adipose tissue browning to enhance energy expenditure and metabolic health in vitro and in human dietary studies. In addition, I have also investigated how polyphenols modulate adipocyte intracellular metabolism to ameliorate insulin resistance. I am author of a publication in Food Research International (Q1) and have presented my work at multiple international conferences with a total of 18 communications. I have contributed to the organization and editorial coordination of the Annual International Congress of Doctoral Students (CAIED) as well as with science communication activities.
